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PE-22-28 5mg: Research Peptide for Neuroprotective & Cognitive Biology Studies
peptology.store is proud to present PE-22-28 5mg, a research-grade peptide supplied for laboratory investigations into neuroprotective signaling, neuronal survival, cognitive biology, synaptic function, and mechanisms associated with neurodegenerative research.
PE-22-28 is a synthetic peptide fragment derived from the activity-dependent neuroprotective protein (ADNP). It has been investigated primarily as a research tool for studying neuronal signaling and neuroprotective mechanisms, including pathways associated with microtubule-associated protein interactions and cellular resilience.
As a dedicated EU peptide supplier and peptide vendor UK, Peptology Store provides research compounds with documented specifications intended to support controlled and reproducible laboratory workflows.
For researchers seeking to buy peptide online for investigations into melanocortin receptor signaling, melanogenesis pathways, or metabolic regulation, Peptology Store offers this premium research with comprehensive documentation and all necessary components in one convenient package. Whether your laboratory is based in London, Berlin, Paris, or anywhere in the European Union, our guaranteed 48 hour delivery peptide service ensures your research supplies arrive when you need them.
The Scientific Foundation of PE-22-28 Research
Discovery and Biological Background
PE-22-28 is a short synthetic peptide derived from a region of activity-dependent neuroprotective protein (ADNP).
ADNP has attracted scientific interest because of its involvement in neuronal development, cytoskeletal regulation, and cellular protection. Research into peptide fragments derived from ADNP has therefore explored whether specific sequences can reproduce selected biological activities of the parent protein.
PE-22-28 has subsequently been investigated in experimental models involving:
- Neuronal survival
- Microtubule-associated signaling
- Synaptic function
- Neuroinflammation
- Cognitive biology
- Neurodegenerative mechanisms
Microtubule and Cytoskeletal Research
One of the important areas of PE-22-28 research involves the neuronal cytoskeleton.
Microtubules are essential structural components of neurons and participate in:
- Axonal transport
- Neuronal architecture
- Intracellular trafficking
- Synaptic organization
- Cellular signaling
- Neuronal maintenance
Research involving PE-22-28 has examined interactions with microtubule-associated proteins and pathways relevant to neuronal stability.
Neuroprotective Signaling
PE-22-28 has been investigated as a peptide capable of influencing cellular pathways associated with neuronal resilience.
Experimental research may examine:
- Neuronal survival
- Cellular stress responses
- Cytoskeletal stability
- Neuroinflammatory signaling
- Oxidative stress
- Synaptic integrity
ADNP-Derived Peptide Research
Because PE-22-28 is derived from ADNP, it provides researchers with a smaller experimental model for investigating selected biological functions associated with the parent protein.
Comparative studies can examine:
- ADNP-associated signaling
- Peptide-protein interactions
- Microtubule regulation
- Cellular protection
- Structure-function relationships
Key Research Applications
Neuroprotection Research
PE-22-28 is primarily investigated in experimental models examining mechanisms of neuronal protection.
Potential research applications include:
- Neuronal Survival: Investigate pathways involved in maintaining neuronal viability
- Cellular Stress: Examine neuronal responses to experimental stressors
- Neurodegeneration: Study mechanisms associated with neuronal damage
- Cytoskeletal Stability: Investigate microtubule-associated pathways
- Neuroinflammation: Examine relationships between neuronal signaling and inflammatory pathways
Alzheimer’s Disease Research
PE-22-28 has attracted research interest in models associated with Alzheimer’s disease and related neurodegenerative mechanisms.
Researchers may investigate:
- Tau-associated pathology
- Microtubule stability
- Neuronal degeneration
- Synaptic dysfunction
- Neuroinflammatory signaling
- Cognitive-associated cellular pathways
Tau and Microtubule Research
Tau proteins play an important role in stabilizing neuronal microtubules. Abnormal tau phosphorylation and aggregation are central features of several neurodegenerative diseases.
PE-22-28 can therefore be investigated in models examining:
- Tau phosphorylation
- Tau-microtubule interactions
- Microtubule stability
- Axonal transport
- Cytoskeletal organization
Synaptic Biology Research
Synaptic integrity is fundamental to neuronal communication and cognitive function.
Research applications may include:
- Synaptic protein expression
- Neuronal connectivity
- Synaptic signaling
- Activity-dependent pathways
- Neuronal plasticity
Neuroinflammation Research
Neuroinflammation is an important component of many neurodegenerative conditions.
PE-22-28 may be investigated in experimental models examining:
- Microglial activation
- Inflammatory cytokine signaling
- Neuronal-inflammation interactions
- Oxidative stress
- Cellular inflammatory responses
Cognitive and Memory Research
Preclinical research involving ADNP-derived peptides has investigated relationships between peptide activity and cognitive-associated pathways.
Experimental models may examine:
- Learning and memory
- Synaptic plasticity
- Neuronal signaling
- Cognitive-associated molecular pathways
- Neurodegeneration-associated cognitive changes
Quality Assurance: Setting the Standard for Research Compounds
Manufacturing Excellence
peptology.store supplies PE-22-28 5mg with an emphasis on analytical quality and batch traceability.
Quality documentation may include:
- HPLC Purity Analysis: Analytical assessment of peptide purity
- Mass Spectrometry Verification: Molecular identity and molecular-weight confirmation
- Batch-Specific Certificates of Analysis: Documentation associated with the individual production lot
- Lyophilized Research Format: Dry presentation intended for appropriate laboratory storage
-
Research-Use-Only Labelling: Clearly designated for laboratory research
Physical and Chemical Properties
| Molecular Weight (g/mol) | 773.89 g/mol |
| Peptide Sequence | Gly-Val-Ser-Trp-Gly-Leu-Arg (GVSWGLR) |
| CAS Number | 1801959-12-5 |
| Molecular Formula | C35H55N11O9 |
| Appearance | White to off-white lyophilised powder |
| Melting Point | Not applicable (decomposes before melting) |
| Research Use and Safety | |
| Caution | Handle using appropriate PPE and in compliance with relevant laboratory safety standards. |
| Intended Use | For laboratory research use only. Not for human or veterinary use. |
| Hazard Classification | Not classified as hazardous under GHS for research quantities |
| Storage, Handling and Stability | |
| Storage Temperature, Opened | -20 °C, minimise freeze-thaw cycles |
| Storage Temperature, Unopened | -20 °C recommended for long-term storage |
| Shelf Life | 2 years unopened under recommended conditions |
| Reconstitution Stability | Stable for up to 28 days at 2-8 °C in aqueous solution under sterile conditions |
Stability and Handling
PE-22-28 5mg should be handled according to the product-specific documentation and established laboratory procedures.
- Lyophilized Material: Store according to the temperature specified in the applicable batch documentation.
- Light Protection: Protect the material from unnecessary direct light exposure.
- Moisture Protection: Keep the vial tightly sealed and protected from humidity.
- Reconstituted Material: Establish storage conditions according to validated laboratory stability procedures.
- Aliquoting: Where appropriate, aliquot prepared research solutions to minimize repeated freeze-thaw exposure.
- Temperature Control: Avoid unnecessary temperature fluctuations during storage and handling.
- Documentation: Record preparation and storage conditions as part of the experimental record.
Real-World Research Applications and Investigator Studies
Neuronal Survival Studies
PE-22-28 has been investigated in experimental systems designed to examine neuronal survival and cellular resilience.
Researchers may evaluate:
- Cell viability
- Neuronal morphology
- Stress-response pathways
- Cytoskeletal integrity
- Neuroprotective signaling
Microtubule Stability Studies
The relationship between ADNP-derived peptides and microtubule-associated proteins makes PE-22-28 relevant to cytoskeletal research.
Experimental endpoints can include:
- Microtubule organization
- Tau-associated signaling
- Axonal transport
- Cytoskeletal integrity
- Neuronal morphology
Neurodegenerative Disease Models
PE-22-28 has been investigated in experimental models relevant to neurodegenerative disorders.
Research areas may include:
- Alzheimer’s disease mechanisms
- Tau-associated pathology
- Neuronal degeneration
- Synaptic dysfunction
- Neuroinflammation
Cognitive Research
ADNP-derived peptide research has included experimental models examining learning, memory, and cognitive-associated processes.
Researchers can investigate relationships between peptide exposure and:
- Synaptic signaling
- Neuronal plasticity
- Memory-associated pathways
- Neurodegeneration-associated changes
Key Research Features
- 5mg Research Presentation
- PE-22-28 Synthetic Peptide
- ADNP-Derived Research Compound
- Neuroprotection Research
- Neuronal Survival Studies
- Microtubule Biology
- Tau-Associated Research
- Synaptic Function Studies
- Neuroinflammation Research
- Neurodegenerative Disease Models
- Cognitive Biology Research
- Cytoskeletal Research
- Lyophilized Research Format
- Batch-Specific Documentation
- Research-Use-Only Material
- Laboratory-Oriented Handling Guidance
- EU & UK Research Supply through Peptology Store
Frequently Asked Questions
Q: What is PE-22-28?
A: PE-22-28 is a synthetic peptide derived from the activity-dependent neuroprotective protein (ADNP). It has been investigated as a research tool for studying neuronal signaling, cytoskeletal biology, neuroprotection, and neurodegenerative mechanisms.
Q: What is PE-22-28 5mg used for?
A: PE-22-28 5mg is supplied for laboratory research involving neuronal survival, microtubule biology, tau-associated mechanisms, synaptic function, neuroinflammation, cognitive biology, and neurodegenerative research.
Q: What is the relationship between PE-22-28 and ADNP?
A: PE-22-28 is an experimentally studied peptide fragment derived from ADNP. Researchers use it to investigate selected biological functions associated with the larger ADNP protein.
Q: What research areas commonly investigate PE-22-28?
A: Research applications include neuroprotection, neuronal signaling, microtubule biology, tau research, synaptic function, neuroinflammation, Alzheimer’s disease models, and cognitive research.
Q: Is PE-22-28 studied in Alzheimer’s research?
A: ADNP-derived peptides, including PE-22-28-related research compounds, have been investigated in experimental models relevant to Alzheimer’s disease and associated mechanisms such as tau pathology, neuronal survival, and cytoskeletal stability.
Q: Does PE-22-28 interact with microtubule-associated pathways?
A: PE-22-28 research has focused on ADNP-associated interactions with neuronal cytoskeletal and microtubule-related pathways, making it relevant to experimental studies of neuronal structure and intracellular transport.
Q: How should PE-22-28 be stored?
A: Store the lyophilized material according to the product-specific storage instructions. Protect it from moisture, unnecessary light exposure, and unsuitable temperatures. Reconstituted material should be handled according to an appropriate laboratory stability protocol.
Q: Is PE-22-28 suitable for human consumption?
A: No. PE-22-28 5mg supplied by peptology.store is intended for research and laboratory use only and is not marketed as a human or veterinary therapeutic.
Q: Can PE-22-28 be used in cell-based research?
A: PE-22-28 can be investigated in appropriate in-vitro experimental systems involving neuronal or other relevant cellular models. Researchers should establish concentrations, solvents, controls, and exposure periods according to validated laboratory protocols.
Q: What documentation is available with PE-22-28?
A: Batch-specific analytical documentation may include a Certificate of Analysis (COA) and other analytical information depending on the production batch.
Q: Do you offer bulk quantities of PE-22-28?
A: Bulk research supply can be discussed for qualified laboratory and institutional requirements. Researchers can contact Peptology Store regarding current availability and documentation.
Q: Do you ship PE-22-28 to EU countries?
A: Research-product availability and shipping options for PE-22-28 5mg can be confirmed through peptology.store. Researchers should verify applicable destination-country requirements before ordering.
Q: Is PE-22-28 an approved treatment for neurodegenerative disease?
A: No. PE-22-28 is an investigational research peptide. Experimental findings should not be interpreted as establishing approved efficacy or safety for treating Alzheimer’s disease, neurodegeneration, cognitive impairment, or other human conditions.
Advance Your Research with PE-22-28 5mg
Peptology Store provides PE-22-28 5mg for researchers investigating neuroprotective signaling, neuronal survival, microtubule biology, tau-associated mechanisms, synaptic function, neuroinflammation, and cognitive-associated pathways.
Whether your research focuses on neuronal cytoskeletal biology, neurodegenerative mechanisms, synaptic signaling, or ADNP-associated cellular pathways, PE-22-28 provides a defined synthetic peptide model for controlled laboratory investigation.
Order today and experience the peptology.store difference – premium quality, rapid 48-hour delivery across the EU and UK, and expert support for the European research community.
