Premium KPV Peptide 5mg – High-Quality Research Peptide for Sale | 5mg per Vial | ≥99% Purity | 48-Hour Delivery Across EU & UK

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KPV 5mg: Research-Grade Anti-Inflammatory Tripeptide for Cellular & Inflammation Research

peptology.store is proud to present KPV 5mg, a research-grade synthetic tripeptide supplied for laboratory investigations into inflammatory signaling, intestinal inflammation, epithelial biology, immune-cell responses, and cellular stress pathways.

KPV (Lys-Pro-Val) is a three-amino-acid peptide corresponding to the C-terminal sequence of α-melanocyte-stimulating hormone (α-MSH). Research has identified KPV as an experimentally active anti-inflammatory peptide, with studies investigating its effects on NF-κB signaling, pro-inflammatory cytokine production, epithelial responses, and intestinal inflammation.

As a dedicated EU peptide supplier and peptide vendor UK, Peptology Store provides research compounds with documented specifications intended to support controlled laboratory workflows.

For researchers seeking to buy peptide online for investigations into obesity pharmacotherapy, type 2 diabetes, metabolic syndrome, or non-alcoholic fatty liver disease (NAFLD), Peptology Store offers this premium research compound with comprehensive documentation, including Certificates of Analysis and batch-specific purity data . Whether your laboratory is based in London, Berlin, Paris, or anywhere in the European Union, our guaranteed 48 hour delivery peptide service ensures your research continues without interruption.

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The Scientific Foundation of KPV Research

Discovery and Biological Background

KPV is the C-terminal tripeptide sequence of α-MSH and consists of the amino acids Lysine-Proline-Valine (Lys-Pro-Val).

α-MSH is a melanocortin peptide derived from proopiomelanocortin (POMC). Research into α-MSH-derived fragments identified KPV as an important sequence associated with anti-inflammatory activity.

The small size of KPV makes it particularly useful for research investigating short bioactive peptides and their interactions with cellular signaling pathways.

KPV and Inflammatory Signaling

Experimental research has demonstrated that KPV can suppress inflammatory signaling in several cellular models.

Studies have investigated effects involving:

• NF-κB signaling
• MAP kinase pathways
• Pro-inflammatory cytokine production
• Chemokine secretion
• Epithelial-cell inflammatory responses
• Immune-cell signaling

In intestinal epithelial and immune-cell models, KPV was reported to inhibit NF-κB activation and reduce pro-inflammatory cytokine secretion.

PepT1-Mediated Cellular Uptake

One important area of KPV research concerns its interaction with PepT1, a proton-coupled oligopeptide transporter.

Experimental studies reported that KPV can be transported into intestinal epithelial and immune cells through PepT1 and that this mechanism contributes to its observed anti-inflammatory effects in those models.

This provides researchers with an additional model for studying how small peptides can enter cells and influence intracellular inflammatory pathways.

Key Research Applications

Inflammation and Immunology Research

KPV is primarily investigated as an experimental anti-inflammatory tripeptide.

Research applications include:

• NF-κB Signaling: Investigate regulation of inflammatory transcription pathways
• Cytokine Research: Examine changes in pro-inflammatory cytokine expression
• Immune-Cell Studies: Investigate inflammatory responses in immune-cell models
• Epithelial Biology: Study inflammatory signaling in epithelial tissues
• Cellular Stress Research: Examine cellular responses to inflammatory stimuli

Experimental research has reported reductions in inflammatory mediators including IL-1β, IL-6, TNF-α, IFN-γ, and IL-8 in specific cellular and animal models.

Gastrointestinal Research

KPV has been extensively investigated in experimental models of intestinal inflammation.

Research areas include:

• Intestinal epithelial biology
• Colitis models
• Mucosal inflammation
• Gut-barrier function
• Cytokine signaling
• PepT1-mediated peptide transport

In mouse models of DSS- and TNBS-induced colitis, experimental KPV administration reduced inflammatory markers and disease-associated changes.

NF-κB Pathway Research

NF-κB is a major transcriptional regulator involved in inflammatory signaling.

KPV has been investigated for its ability to reduce NF-κB activation in epithelial and immune-cell models.

Researchers can therefore examine:

• IκBα stability
• p65/RelA nuclear translocation
• NF-κB transcriptional activity
• Cytokine expression
• Chemokine secretion

Research in human bronchial epithelial cells reported that KPV inhibited NF-κB signaling and reduced IL-8 and other inflammatory responses.

Airway and Respiratory Research

KPV has also been studied in human bronchial epithelial-cell models.

Experimental research has investigated:

• Airway epithelial inflammation
• TNF-α-induced signaling
• NF-κB activation
• IL-8 secretion
• MMP-9 activity
• Cellular inflammatory responses

These findings provide a research framework for investigating KPV in epithelial inflammatory signaling.

Skin and Inflammatory Biology

Because KPV derives from α-MSH, it has also attracted research interest in inflammatory skin biology.

Research areas include:

• Keratinocyte signaling
• Inflammatory cytokines
• Neutrophil migration
• NF-κB signaling
• Cutaneous inflammatory responses

The anti-inflammatory properties of α-MSH-related peptides, including KPV, have been investigated across multiple experimental inflammation models.

Neuroinflammation Research

KPV-related research has also been extended to inflammatory processes affecting nervous-system tissues.

Experimental studies have investigated α-MSH-derived KPV in models involving:

• Neuroinflammatory signaling
• Microglial responses
• Cytokine regulation
• Oxidative stress
• Inflammation-associated tissue injury

These applications remain primarily experimental and should not be interpreted as evidence of established clinical efficacy.

Quality Assurance: Setting the Standard for Research Compounds

Manufacturing Excellence

peptology.store supplies KPV 5mg with an emphasis on analytical quality and batch traceability.

Quality documentation may include:

• HPLC Purity Analysis: Analytical assessment of peptide purity
• Mass Spectrometry Verification: Molecular identity and molecular-weight confirmation
• Batch-Specific Certificates of Analysis: Documentation associated with individual production lots
• Lyophilized Research Format: Dry presentation intended for appropriate laboratory handling
• Research-Use-Only Labelling: Clearly designated for laboratory research

• Batch Traceability: Documentation intended to support reproducible experimental work

  Physical and Chemical Properties

Molecular Weight (g/mol)	342.43 g/mol
Peptide Sequence	Lys-Pro-Val
Molecular Formula	C16H30N4O4
Physical Appearance	white lyophilised solid
Form	Sterile filtered white lyophilized (freeze-dried)
Solubility	Aqueous soluble
Appearance	White to off-white lyophilised powder
Melting Point	Not applicable (decomposes before melting)
Analytical and Quality Control
HPLC Result	Shows min 99% Purity
Mass Spectrum	Consistent with structure
Purity %	>99%
Research Use and Safety
Caution	Research use only / Not for human or veterinary use
Intended Use	For laboratory research use only. Not for human or veterinary use.
Hazard Classification	Not classified as hazardous under GHS for research quantities
Storage, Handling and Stability
Storage Temperature, Opened	Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18°C. Upon reconstitution of the peptide it should be stored at 4°C between 2-21 days and for future use below -18°C.
Storage Temperature, Unopened	-20 °C recommended for long-term storage
Shelf Life	2 years unopened under recommended conditions
Reconstitution Stability	Stable for up to 28 days at 2-8 °C in aqueous solution under sterile conditions

Stability and Handling

KPV 5mg should be handled according to the product-specific documentation and established laboratory procedures.

• Lyophilized Material: Store according to the temperature specified in the batch documentation.
• Light Protection: Protect the material from unnecessary direct light exposure.
• Moisture Protection: Keep the vial tightly sealed and protected from humidity.
• Reconstituted Material: Establish storage conditions according to validated laboratory procedures and available stability information.
• Aliquoting: Where appropriate, aliquot prepared research solutions to reduce repeated freeze-thaw exposure.
• Temperature Control: Avoid unnecessary temperature fluctuations.
• Documentation: Record preparation and storage conditions as part of the experimental record.

Researchers should consult the batch-specific COA and product documentation before establishing long-term solution-storage conditions.

Real-World Research Applications and Investigator Studies

Intestinal Inflammation Studies

One of the best-characterized areas of KPV research involves intestinal inflammation.

In experimental studies using human intestinal epithelial and immune-cell models, KPV inhibited inflammatory signaling and reduced pro-inflammatory cytokine production. In mouse models of chemically induced colitis, KPV administration reduced inflammatory changes.

PepT1 Transport Studies

Research has identified PepT1 as an important transporter for KPV in intestinal epithelial and immune cells.

This provides a useful experimental system for studying:

• Peptide transport
• Intracellular peptide signaling
• Epithelial-cell responses
• Immune-cell responses
• Inflammation-associated transporter expression

Airway Inflammation Studies

Human bronchial epithelial-cell experiments have investigated KPV in response to TNF-α and other inflammatory stimuli.

Researchers reported dose-dependent suppression of NF-κB activity and reductions in inflammatory mediators such as IL-8 and MMP-9 under the experimental conditions used.

Cytokine Signaling Studies

KPV has been investigated for its effects on several pro-inflammatory cytokines.

Experimental models have examined:

• IL-1β
• IL-6
• TNF-α
• IFN-γ
• IL-8

These findings provide a basis for studying KPV as a molecular tool for inflammatory-pathway research.

Key Research Features

• 5mg Research Presentation
• Synthetic Lys-Pro-Val Tripeptide
• C-terminal Sequence of α-MSH
• Anti-Inflammatory Research
• NF-κB Signaling Studies
• Cytokine Modulation Research
• PepT1 Transport Research
• Intestinal Inflammation Studies
• Colitis Model Research
• Epithelial-Cell Biology
• Airway Inflammation Research
• Immune-Cell Signaling
• Cellular Stress Research
• Neuroinflammation Research
• Lyophilized Research Format
• Batch-Specific Documentation
• Research-Use-Only Material
• Laboratory-Oriented Handling Guidance
• EU & UK Research Supply through Peptology Store

Frequently Asked Questions

Q: What is KPV?

A: KPV is the tripeptide Lys-Pro-Val, corresponding to the C-terminal three amino acids of α-melanocyte-stimulating hormone (α-MSH). It has been extensively investigated for its anti-inflammatory activity in cellular and animal research models.

Q: What is KPV 5mg used for?

A: KPV 5mg is supplied for laboratory research involving inflammatory signaling, NF-κB pathways, intestinal inflammation, epithelial biology, PepT1-mediated transport, cytokine regulation, and related cellular mechanisms.

Q: What is the sequence of KPV?

A: KPV consists of three amino acids: Lysine-Proline-Valine (Lys-Pro-Val). It corresponds to residues 11–13 of α-MSH.

Q: What is the relationship between KPV and α-MSH?

A: KPV is the C-terminal tripeptide of α-MSH. Research into α-MSH-derived fragments identified KPV as an important sequence associated with anti-inflammatory activity.

Q: What receptor does KPV act on?

A: The mechanism of KPV is not fully resolved. Research indicates that its anti-inflammatory effects in intestinal epithelial and immune-cell models can involve PepT1-mediated uptake and intracellular effects on inflammatory signaling. Some studies have also investigated possible melanocortin-receptor involvement, but evidence indicates that KPV’s principal anti-inflammatory activity in certain models is independent of classical melanocortin-receptor signaling.

Q: Does KPV affect NF-κB signaling?

A: Yes. Experimental studies have reported inhibition of NF-κB activation by KPV in intestinal and airway epithelial models, together with reductions in inflammatory mediator production.

Q: Has KPV been studied for intestinal inflammation?

A: Yes. KPV has been investigated in human intestinal epithelial and immune-cell models as well as mouse models of DSS- and TNBS-induced colitis. Experimental administration reduced several inflammatory markers in these models.

Q: Has KPV been studied in airway inflammation?

A: Yes. Research using human bronchial epithelial cells found that KPV suppressed TNF-α-associated NF-κB signaling and reduced inflammatory mediators including IL-8 and MMP-9 under experimental conditions.

Q: Is KPV suitable for human consumption?

A: No. KPV 5mg supplied by peptology.store is intended for research and laboratory use only and is not marketed as an approved human therapeutic.

Q: Can KPV be used in cell-based research?

A: KPV has been investigated in several in-vitro cellular systems, including intestinal epithelial cells, immune-cell models, and bronchial epithelial cells. Researchers should establish concentrations, controls, exposure periods, and assay conditions according to validated laboratory protocols.

Q: How should KPV 5mg be stored?

A: Store the lyophilized material according to the product-specific storage documentation, protecting it from moisture, excessive light, and unsuitable temperatures. Reconstituted material should be handled according to an appropriate laboratory stability protocol.

Q: What documentation is available with KPV orders?

A: A batch-specific Certificate of Analysis (COA) may provide analytical information for the supplied material. Additional analytical documentation should be confirmed for the specific production batch.

Q: What research areas commonly investigate KPV?

A: KPV is investigated in inflammation research, intestinal biology, colitis models, epithelial signaling, NF-κB research, cytokine regulation, PepT1 transport, airway inflammation, immune-cell biology, and cellular stress research.

Q: Do you offer bulk quantities of KPV?

A: Bulk research supply can be discussed for qualified laboratory and institutional requirements. Researchers can contact Peptology Store regarding current availability and batch documentation.

Q: Do you ship KPV 5mg to UK & EU countries?

A: Shipping availability for KPV 5mg can be confirmed through peptology.store. Researchers should verify applicable destination-country requirements before ordering.

Q: Does KPV have established therapeutic effects in humans?

A: The published evidence cited here is predominantly from cellular and animal research models. These findings support continued investigation but do not establish KPV as an approved treatment for inflammatory or gastrointestinal diseases.

Advance Your Research with KPV 5mg

Peptology Store provides KPV 5mg for researchers investigating inflammatory signaling, epithelial biology, intestinal inflammation, cytokine regulation, PepT1-mediated peptide transport, and related cellular mechanisms.

Whether your research focuses on NF-κB signaling, gastrointestinal inflammation, airway epithelial responses, immune-cell biology, or short-peptide cellular transport, KPV provides a defined tripeptide model for controlled laboratory investigation.

The existing literature provides substantial preclinical evidence for KPV-associated anti-inflammatory activity, particularly in intestinal and epithelial models, while human therapeutic efficacy remains unestablished.

Order today and experience the peptology.store difference – premium quality, rapid 48-hour delivery across the EU and UK, and expert support for the European research community.