FOXO4-DRI 10mg (Proxofim): A Peptide Tool for Cellular Senescence Research
peptology.store presents FOXO4-DRI 10mg (Proxofim) as a research compound intended for laboratory investigation of cellular senescence, FOXO4-related signaling, apoptosis, and aging-associated cellular pathways.
FOXO4-DRI is a synthetic peptide-based research molecule designed around the interaction between FOXO4 and p53, two proteins involved in cellular stress responses, survival signaling, and apoptosis. Its research profile has made it an important experimental tool for investigating mechanisms associated with senescent-cell biology.
Our collaboration with certified GMP facilities ensures that every batch of FOXO4 meets rigorous quality control specifications, making peptology.store the preferred destination for researchers seeking to buy peptide online UK and across the European Union. The compound is supplied with comprehensive documentation, including Certificates of Analysis and batch-specific purity data .
For researchers seeking to buy peptide online for investigations into muscle preservation, bone density, metabolic regulation, or age-related sarcopenia, peptology.store offers FOXO4-DRI 10mg (Proxofim) with guaranteed 48 hour delivery peptide service. Whether your laboratory is based in London, Berlin, Paris, or anywhere in the European Union, our rapid shipping ensures your research continues without interruption.
The Scientific Foundation of FOXO4-DRI Research
Understanding FOXO4 and Cellular Senescence
FOXO4 (Forkhead Box O4) belongs to the FOXO family of transcription factors involved in cellular stress responses, metabolism, apoptosis, DNA-damage responses, and longevity-associated signaling.
Cellular senescence is a state in which cells permanently reduce their proliferative capacity while remaining metabolically active. Senescent cells can accumulate with age and may influence surrounding tissues through the secretion of inflammatory and other signaling molecules.
FOXO4 has attracted research interest because of its interaction with p53, a major regulator of cellular stress and apoptosis.
FOXO4-DRI and the FOXO4–p53 Interaction
FOXO4-DRI is a synthetic peptide designed to interfere with the interaction between FOXO4 and p53.
Experimental research has investigated whether disrupting this interaction can alter the survival behavior of senescent cells and promote apoptosis in selected cellular models.
This makes FOXO4-DRI particularly relevant to laboratory studies examining:
- FOXO4–p53 protein interactions
- Cellular senescence
- Apoptotic signaling
- Aging-associated cellular changes
- Stress-response pathways
- Senescent-cell survival mechanisms
Key Research Applications
Cellular Senescence Studies
FOXO4-DRI is primarily investigated as a research tool for understanding cellular senescence.
Researchers can study:
- Senescent-cell survival mechanisms
- FOXO4-dependent signaling
- Changes in cellular viability
- Senescence-associated phenotypes
- Molecular pathways associated with aging
Apoptosis Research
The FOXO4–p53 interaction is closely associated with cellular survival and apoptotic signaling.
FOXO4-DRI provides an experimental system for investigating:
- p53-associated apoptosis
- Protein–protein interaction disruption
- Mitochondrial and cellular stress responses
- Changes in apoptotic signaling
- Selective responses in senescent-cell models
Aging and Longevity Research
FOXO transcription factors are extensively studied in the biology of aging and cellular stress.
FOXO4-DRI can therefore be investigated in experimental models examining:
- Age-associated cellular accumulation
- Cellular stress responses
- Senescence-associated signaling
- Tissue-aging mechanisms
- Molecular pathways connected with longevity research
Protein–Protein Interaction Research
One of the principal research interests surrounding FOXO4-DRI is its ability to serve as a molecular tool for studying protein–protein interactions.
Researchers can investigate how modifying FOXO4–p53 interactions affects downstream cellular behavior under controlled laboratory conditions.
Cancer and Cell-Biology Research
Because FOXO4 and p53 are involved in cell-cycle regulation, apoptosis, and cellular stress responses, FOXO4-DRI may also be investigated in experimental cancer and cell-biology models.
Such research may examine:
- Tumor-cell signaling
- p53-dependent pathways
- Cellular survival mechanisms
- Apoptotic responses
- Senescence-associated phenotypes
Research Significance
FOXO4-DRI provides researchers with a specialized experimental tool for studying the relationship between cellular senescence, FOXO4 signaling, and p53-mediated apoptosis.
Its primary value is not as a general-purpose peptide but as a molecular probe for investigating specific biological mechanisms under controlled research conditions.
Quality Assurance and Analytical Documentation
peptology.store can provide batch-specific analytical documentation where available, allowing researchers to evaluate the identity and quality characteristics of the material supplied.
Recommended analytical documentation may include:
- HPLC Analysis: Chromatographic assessment of peptide purity
- Mass Spectrometry: Molecular-weight and identity confirmation
- Batch-Specific COA: Documentation associated with the individual production batch
- Research-Use-Only Labeling: Material designated for laboratory research rather than human or veterinary use
- Identity Verification: Analytical confirmation of the supplied compound where documented
| Molecular Weight (g/mol) | 5358.05 g/mol |
| Peptide Sequence | H-D-Leu-D-Thr-D-Leu-D-Arg-D-Lys-D-Glu-D-Pro-D-Ala-D-Ser-D-Glu-D-Ile-D-Ala-D-Gln-D-Ser-D-Ile-D-Leu-D-Glu-D-Ala-D-Tyr-D-Ser-D-Gln-D-Asn-D-Gly-D-Trp-D-Ala-D-Asn-D-Arg-D-Arg-D-Ser-D-Gly-D-Gly-D-Lys-D-Arg-D-Pro-D-Pro-D-Pro-D-Arg-D-Arg-D-Arg-D-Gln-D-Arg-D-Arg-D |
| Physical and Chemical Properties | |
| Molecular Formula | C228H388N86O64 |
| Physical Appearance | white lyophilised solid |
| Form | Sterile filtered white lyophilized (freeze-dried) |
| Solubility | Aqueous soluble |
| Appearance | White to off-white lyophilised powder |
| Melting Point | Not applicable (decomposes before melting) |
| Analytical and Quality Control | |
| HPLC Result | Shows min 99% Purity |
| Mass Spectrum | Consistent with structure |
| Purity % | >99% |
| Research Use and Safety | |
| Caution | Research use only / Not for human or veterinary use |
| Intended Use | For laboratory research use only. Not for human or veterinary use. |
| Hazard Classification | Not classified as hazardous under GHS for research quantities |
| Storage, Handling and Stability | |
| Storage Temperature, Opened | Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18°C. Upon reconstitution of the peptide it should be stored at 4°C between 2-21 days and for future use below -18°C. |
| Storage Temperature, Unopened | -20 °C recommended for long-term storage |
| Shelf Life | 2 years unopened under recommended conditions |
| Reconstitution Stability | Stable for up to 28 days at 2-8 °C in aqueous solution under sterile conditions |
Stability and Handling
FOXO4-DRI (Proxofim) should be handled according to the manufacturer’s current batch-specific documentation and established laboratory procedures.
- Lyophilized Material: Store according to the supplier’s specified temperature and storage conditions.
- Light Protection: Keep in the original container and protect from direct light.
- Moisture Protection: Keep the container tightly sealed and protected from moisture.
- Reconstituted Solutions: Follow validated laboratory procedures and the supplier’s batch-specific recommendations for storage and stability after reconstitution.
- Freeze/Thaw Protection: Where applicable, aliquot prepared research solutions to minimize repeated freeze/thaw cycles.
- Transportation: Use appropriate temperature-controlled packaging when required by the compound’s stability specifications.
Real-World Research Applications and Investigator Experiences
Cellular Senescence Research
FOXO4-DRI has attracted research interest as an experimental tool for investigating cellular senescence and the molecular mechanisms that contribute to senescent-cell survival.
Research applications include:
- Investigation of senescent-cell viability
- Study of FOXO4-associated signaling
- Examination of senescence-associated cellular phenotypes
- Investigation of molecular pathways involved in cellular survival
- Comparative studies of senescent and non-senescent cells
FOXO4–p53 Interaction Studies
One of the principal research applications of FOXO4-DRI is the investigation of the interaction between FOXO4 and p53, an important regulator of cellular stress and apoptosis.
Researchers can use FOXO4-DRI as an experimental molecular tool to investigate:
- FOXO4–p53 protein interactions
- Changes in p53-associated signaling
- Protein–protein interaction disruption
- Cellular responses following alteration of FOXO4–p53 signaling
- Downstream apoptosis-related pathways
Apoptosis Research
The relationship between FOXO4 and p53 has implications for cellular survival and apoptosis research.
FOXO4-DRI can therefore be investigated in laboratory models examining:
- Apoptotic signaling
- Cellular stress responses
- Changes in cell viability
- p53-associated pathways
- Molecular mechanisms influencing senescent-cell survival
Aging and Longevity Research
FOXO transcription factors are widely investigated in aging biology and cellular stress research.
FOXO4-DRI provides an experimental tool for investigating:
- Age-associated cellular senescence
- Cellular stress responses
- Senescent-cell accumulation
- FOXO-related signaling pathways
- Molecular mechanisms associated with cellular aging
Cancer and Cell-Biology Research
Because FOXO4 and p53 participate in pathways associated with cell-cycle regulation, stress responses, and apoptosis, FOXO4-DRI may also be investigated in selected experimental cancer and cell-biology models.
Potential research areas include:
- Tumor-cell signaling
- p53-associated cellular responses
- Cell survival mechanisms
- Apoptosis pathways
- Senescence-associated phenotypes
Key Research Features
- Specialized Molecular Research Tool: Designed for investigation of FOXO4-associated cellular pathways
- FOXO4–p53 Research: Enables experimental investigation of FOXO4 and p53 protein interactions
- Cellular Senescence Research: Useful for laboratory studies examining senescent-cell biology
- Apoptosis Studies: Supports investigation of cellular survival and programmed-cell-death pathways
- Aging Biology: Relevant to experimental research into cellular aging and senescence
- Protein–Protein Interaction Studies: Provides a tool for examining molecular interaction mechanisms
- Cell Signaling Research: Suitable for controlled investigation of downstream signaling responses
- Cancer Biology Research: Potentially useful in selected laboratory models involving FOXO4 and p53 pathways
- Batch Documentation: Batch-specific analytical documentation should be reviewed where available
- Research-Grade Material: Intended for laboratory and research use only
Frequently Asked Questions
Q: Is FOXO4-DRI suitable for human consumption?
A: No. FOXO4-DRI 10mg (Proxofim) from peptology.store is presented as a research-use-only compound intended for laboratory investigation. It should not be represented as an approved medicine, dietary supplement, or material intended for human or veterinary administration. Researchers should handle it according to applicable institutional safety procedures and local regulations.
Q: What purity level can I expect when I buy FOXO4-DRI from peptology.store?
A: Purity should be confirmed from the batch-specific Certificate of Analysis (COA) supplied for the material. Where available, analytical documentation may include HPLC and mass-spectrometry results for the specific batch.
Q: How should I store FOXO4-DRI for long-term stability?
A: Store FOXO4-DRI according to the supplier’s current batch-specific storage recommendations. Lyophilized material should generally be protected from excessive moisture, heat, and direct light. For reconstituted material, follow the validated storage conditions specified by the supplier or laboratory protocol.
Q: What is the solubility of FOXO4-DRI for in-vitro studies?
A: Solubility can depend on the formulation, solvent, concentration, and experimental conditions. Researchers should consult the batch documentation and establish an appropriate solvent system through their laboratory’s validated protocol before beginning an experiment.
Q: What is FOXO4-DRI primarily studied for?
A: FOXO4-DRI is primarily investigated as an experimental molecular tool for studying cellular senescence, FOXO4–p53 interactions, apoptosis, and cellular stress signaling.
Q: What documentation do you provide with FOXO4-DRI orders?
A: Batch-specific documentation should be provided where available. This may include a Certificate of Analysis (COA) containing analytical information for the individual production batch, with additional HPLC or mass-spectrometry documentation where supplied.
Q: What research areas commonly use FOXO4-DRI?
A: Research applications include:
- Cellular senescence studies
- FOXO4–p53 interaction research
- Apoptosis and cell-survival studies
- Aging and longevity biology
- Cellular stress-response research
- Protein–protein interaction studies
- Cell-signaling research
- Selected cancer and cell-biology models
Q: Has FOXO4-DRI been studied in research models?
A: Yes. FOXO4-DRI has been investigated in experimental models examining the relationship between FOXO4, p53, cellular senescence, and apoptosis. Findings from these models should not be interpreted as evidence of established therapeutic efficacy in humans.
Q: What is the mechanism of action of FOXO4-DRI?
A: FOXO4-DRI has been investigated as a peptide-based molecular tool designed to interfere with the FOXO4–p53 protein interaction. Researchers use this mechanism to study how altering the interaction can influence cellular survival and apoptosis in experimental systems.
Q: How does FOXO4-DRI relate to cellular senescence research?
A: Cellular senescence involves cells entering a stable state of reduced proliferation while remaining metabolically active. FOXO4 has been studied as part of the signaling network that contributes to the survival of senescent cells. FOXO4-DRI provides an experimental approach for investigating this relationship.
Q: Does FOXO4-DRI affect apoptosis?
A: FOXO4-DRI has been investigated in experimental systems for its relationship to p53-associated apoptotic signaling. Researchers can use it to study whether disruption of FOXO4–p53 interactions alters cellular survival and apoptosis under controlled laboratory conditions.
Q: Can FOXO4-DRI be used in aging research?
A: Yes. FOXO4-DRI is relevant to experimental research examining cellular senescence and age-associated cellular changes. However, laboratory findings should not be presented as evidence that FOXO4-DRI reverses aging or extends human lifespan.
Q: Can FOXO4-DRI be used in cancer research?
A: FOXO4 and p53 participate in pathways involved in cellular stress, proliferation, and apoptosis, making FOXO4-DRI relevant to selected experimental cancer-biology studies. Its use in such research should be interpreted as a laboratory investigation rather than evidence of an established cancer treatment.
Q: Is FOXO4-DRI an approved therapeutic compound?
A: FOXO4-DRI should be treated as a research compound rather than an approved therapeutic product. Researchers should verify the regulatory status applicable to their jurisdiction and intended laboratory use before obtaining or handling the material.
Q: What is the intended use of FOXO4-DRI 10mg?
A: FOXO4-DRI 10mg (Proxofim) is intended for research and laboratory use only, particularly for experimental studies involving FOXO4 signaling, p53 interactions, cellular senescence, apoptosis, and related molecular pathways.
Q: Do you offer bulk quantities of FOXO4-DRI for institutional research?
A: Yes. We accommodate bulk orders for qualified research institutions and laboratories. Contact our team for volume pricing, custom requirements, and supply arrangements for ongoing research programs.
Q: Do you ship FOXO4-DRI to EU countries?
A: Availability and shipping options for FOXO4-DRI (Proxofim) depend on the destination and applicable regulations. Orders should be handled in accordance with local laws and institutional research requirements. Appropriate protective packaging should be used during transportation to help maintain compound integrity.
Q: Can FOXO4-DRI be used in cell culture studies?
A: Yes. FOXO4-DRI has been investigated in experimental cell-based models, including studies of cellular senescence, p53 signaling, fibroblast biology, and senescent-cell apoptosis. Researchers should use a validated concentration and solvent system appropriate for their specific experimental protocol and follow the accompanying batch-specific documentation.
Q: What research areas are commonly associated with FOXO4-DRI?
A: FOXO4-DRI is primarily investigated in cellular senescence, FOXO4-p53 signaling, apoptosis, aging biology, senescent-cell clearance, fibroblast research, and regenerative-cell research. Current evidence remains predominantly preclinical.
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