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Ipamorelin 5mg: Research-Grade Growth Hormone Secretagogue for Advanced Endocrine Studies
peptology.store is proud to present Ipamorelin 5mg, a research-grade synthetic pentapeptide supplied for laboratory investigations into growth hormone secretagogue receptor signaling, pituitary physiology, endocrine regulation, intracellular signaling, and neuroendocrine biology.
Ipamorelin is a synthetic pentapeptide with the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH₂. It was developed as a growth hormone secretagogue and has been characterized experimentally as a selective agonist of the growth hormone secretagogue receptor (GHSR).
As a dedicated EU peptide supplier and peptide vendor UK, Peptology Store provides research compounds with documented specifications and batch-specific analytical information intended to support controlled laboratory workflows.
For researchers seeking to buy peptide online for investigations into immunology, T-cell development, gerontology, or cellular regeneration, Peptology Store offers this premium compound with comprehensive documentation, including Certificates of Analysis and batch-specific purity data. Whether your laboratory is based in London, Berlin, Paris, or anywhere in the European Union, our guaranteed 48 hour delivery peptide service ensures your research continues without interruption.
The Scientific Foundation of Ipamorelin Research
Discovery and Development
Ipamorelin was developed during research into synthetic growth hormone secretagogues and was characterized in a 1998 study as a potent GH-releasing pentapeptide. The published sequence is Aib-His-D-2-Nal-D-Phe-Lys-NH₂.
Experimental studies demonstrated GH-releasing activity in cultured rat pituitary cells as well as in animal models. Pharmacological studies indicated that ipamorelin stimulates GH release through a GHRP-like receptor rather than through the classical GHRH receptor.
Structure and Classification
Ipamorelin is a pentapeptide and a member of the growth hormone secretagogue family.
According to PubChem, its molecular formula is C₃₈H₄₉N₉O₅, molecular weight approximately 711.9 g/mol, and CAS number 170851-70-4.
Its research profile makes it useful for investigating:
- Growth hormone secretion
- GHSR pharmacology
- Pituitary somatotroph signaling
- Endocrine regulation
- Receptor-mediated signaling
- Neuroendocrine physiology
GHSR Signaling
Ipamorelin has been characterized as a ligand of the growth hormone secretagogue receptor (GHSR). GHSR activation provides an experimental model for studying receptor-mediated regulation of pituitary GH secretion.
Researchers can use ipamorelin to investigate:
- GHSR activation
- Receptor pharmacology
- Growth hormone release
- Intracellular signaling
- Secretagogue response profiles
- Receptor sensitivity and desensitization
Selectivity Research
One of the distinguishing features reported in the original pharmacological characterization was the relative selectivity of ipamorelin for GH release. In the swine experiments described in that study, ipamorelin did not significantly increase ACTH or cortisol compared with the effects observed with GHRP-2 and GHRP-6.
This makes ipamorelin useful for comparative research investigating how different growth hormone secretagogues influence endocrine pathways.
Key Research Applications
Growth Hormone and Pituitary Research
Ipamorelin is widely investigated as an experimental growth hormone secretagogue.
Research applications include:
- Somatotroph Studies: Investigate GH secretion from pituitary cells
- GHSR Research: Examine receptor-mediated signaling
- Endocrine Regulation: Study mechanisms controlling GH secretion
- Secretagogue Pharmacology: Compare different GH-releasing compounds
- Pituitary Physiology: Investigate cellular responses to receptor activation
GHSR Receptor Research
Ipamorelin provides a defined experimental ligand for studies involving GHSR biology.
Researchers may investigate:
- Receptor activation
- Ligand-receptor interactions
- Concentration-response relationships
- Signal transduction
- Receptor sensitivity
- Receptor desensitization
Comparative Secretagogue Research
Ipamorelin can be studied alongside GHRP-2, GHRP-6, hexarelin, and GHRH-related compounds.
Comparative experiments can examine:
- Relative GH-releasing activity
- Receptor selectivity
- Endocrine signaling differences
- Intracellular responses
- Duration of receptor-mediated effects
The original pharmacological study compared ipamorelin with GHRP-2 and GHRP-6 and found distinct potency and endocrine-response profiles.
Neuroendocrine Research
Because GHSR signaling connects receptor activity with pituitary endocrine responses, ipamorelin can be incorporated into studies examining:
- Neuroendocrine communication
- Hormonal regulation
- Pituitary signaling
- Receptor distribution
- Endocrine feedback mechanisms
Pharmacokinetic and Pharmacodynamic Research
Ipamorelin has also been investigated in human pharmacokinetic/pharmacodynamic research. One study in healthy male volunteers characterized dose-dependent pharmacokinetics and the temporal relationship between ipamorelin exposure and GH release.
These studies provide a basis for investigating:
- Peptide disposition
- Exposure-response relationships
- GH response kinetics
- Pharmacodynamic modeling
- Receptor-mediated endocrine responses
Quality Assurance: Setting the Standard for Research Compounds
Manufacturing Excellence
peptology.store supplies Ipamorelin 5mg with an emphasis on analytical traceability and research reproducibility.
Quality documentation may include:
- HPLC Purity Analysis: Analytical assessment of peptide purity
- Mass Spectrometry Verification: Molecular identity and molecular-weight confirmation
- Batch-Specific Certificates of Analysis: Documentation associated with individual production lots
- Lyophilized Presentation: Dry research format for appropriate laboratory storage
- Research-Use-Only Labelling: Clearly designated for laboratory research
Physical and Chemical Properties
| Molecular Weight (g/mol) | 711.868 g/mol |
| Peptide Sequence | H-Aib-His-D-2Nal-D-Phe-Lys-NH2 |
| Molecular Formula | C38H49N9O5 |
| Physical Appearance | White lyophilised solid |
| Form | Sterile filtered white lyophilized (freeze-dried) |
| Solubility | Aqueous soluble |
| Appearance | White to off-white lyophilised powder |
| Melting Point | Not applicable (decomposes before melting) |
| Analytical and Quality Control | |
| HPLC Result | Shows min 98% purity |
| Mass Spectrum | Consistent with structure |
| Purity % | >98% |
| Research Use and Safety | |
| Caution | Research use only / Not for human or veterinary use |
| Intended Use | For laboratory research use only. Not for human or veterinary use. |
| Hazard Classification | Not classified as hazardous under GHS for research quantities |
| Storage, Handling and Stability | |
| Storage Temperature, Opened | Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18°C. Upon reconstitution of the peptide it should be stored at 4°C between 2-21 days and for future use below -18°C. |
| Storage Temperature, Unopened | -20 °C recommended for long-term storage |
| Shelf Life | 2 years unopened under recommended conditions |
| Reconstitution Stability | Stable for up to 28 days at 2-8 °C in aqueous solution under sterile conditions |
Stability and Handling
Ipamorelin 5mg should be handled according to the supplier’s batch-specific documentation and established laboratory procedures.
- Lyophilized Material: Store under the temperature conditions specified by the product documentation.
- Light Protection: Protect the material from unnecessary direct light exposure.
- Moisture Protection: Keep the vial tightly sealed and protected from humidity.
- Reconstituted Material: Establish solution-storage conditions according to validated laboratory procedures and available stability information.
- Aliquoting: Where appropriate, aliquot prepared research solutions to reduce repeated freeze-thaw exposure.
- Temperature Control: Avoid unnecessary temperature fluctuations.
- Documentation: Record preparation and storage conditions as part of the experimental record.
Real-World Research Applications and Investigator Studies
Pituitary Cell Studies
The original characterization of ipamorelin demonstrated GH release from primary rat pituitary cells and showed activity comparable to GHRP-6 in that experimental system.
This makes ipamorelin useful for studying:
- Somatotroph responses
- GH secretion
- Receptor-mediated signaling
- Secretagogue pharmacology
- Concentration-response relationships
Animal Endocrine Research
Ipamorelin has been evaluated in animal models including rats and pigs.
The original study reported GH-releasing activity in anesthetized rats and conscious swine, providing experimental evidence for its activity as a growth hormone secretagogue.
Selective Endocrine Signaling Studies
The original pharmacological characterization found that ipamorelin produced GH release without significantly increasing ACTH or cortisol in the swine experiments described, distinguishing it from some other GHRP compounds evaluated in the same study.
Human Pharmacokinetic Research
Ipamorelin has also been studied in healthy human volunteers. A pharmacokinetic/pharmacodynamic study characterized its disposition and GH response following controlled infusion, reporting a short terminal half-life of approximately two hours under the study conditions.
These findings are useful for pharmacological research but do not establish the research product as an approved therapeutic formulation.
Comparative Growth Hormone Secretagogue Research
Ipamorelin can be compared with other secretagogues to examine differences in potency, efficacy, selectivity, and endocrine response.
Potential comparison compounds include:
- GHRP-2
- GHRP-6
- Hexarelin
- GHRH-related peptides
- Other GHSR ligands
Key Research Features
- 5mg Research Presentation
- Synthetic Growth Hormone Secretagogue
- Pentapeptide Structure
- GHSR-Related Research
- Pituitary Physiology Studies
- Growth Hormone Signaling Research
- Receptor Pharmacology
- Comparative Secretagogue Research
- Neuroendocrine Research
- Pharmacokinetic Research
- Pharmacodynamic Research
- Receptor Selectivity Studies
- Lyophilized Research Format
- Batch-Specific Documentation
- Research-Use-Only Material
- Laboratory-Oriented Handling Guidance
- EU & UK Research Supply through Peptology Store
Frequently Asked Questions
Q: What is Ipamorelin?
A: Ipamorelin is a synthetic pentapeptide growth hormone secretagogue with the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH₂. It has been experimentally characterized as a ligand acting through a GHRP-like receptor and is primarily studied in relation to GHSR and growth hormone signaling.
Q: What is Ipamorelin 5mg used for?
A: Ipamorelin 5mg is supplied for laboratory research involving GHSR signaling, pituitary physiology, growth hormone secretion, receptor pharmacology, endocrine regulation, pharmacokinetics, and comparative secretagogue research.
Q: What receptor does Ipamorelin target?
A: Ipamorelin has been characterized as acting through a GHRP-like receptor, corresponding to the growth hormone secretagogue receptor (GHSR).
Q: What is the molecular weight of Ipamorelin?
A: PubChem lists the molecular weight of Ipamorelin as approximately 711.9 g/mol.
Q: What is the amino acid sequence of Ipamorelin?
A: The published sequence is Aib-His-D-2-Nal-D-Phe-Lys-NH₂.
Q: What research areas commonly investigate Ipamorelin?
A: Research applications include growth hormone signaling, pituitary physiology, GHSR pharmacology, endocrine regulation, neuroendocrine research, pharmacokinetic studies, and comparative secretagogue research.
Q: How should Ipamorelin be stored?
A: Store the lyophilized material according to the product-specific storage documentation. Protect it from moisture, unnecessary light exposure, and unsuitable temperatures. Reconstituted material should be handled according to a validated laboratory stability protocol.
Q: Is Ipamorelin suitable for human consumption?
A: No. Ipamorelin 5mg supplied by peptology.store is intended for research and laboratory use only and is not supplied as an approved therapeutic product.
Q: Can Ipamorelin be used in cell-based research?
A: Ipamorelin can be investigated in appropriate in-vitro experimental systems, including models involving pituitary or GHSR-associated signaling. Researchers should establish concentrations, exposure times, controls, and assay conditions according to validated laboratory protocols.
Q: Has Ipamorelin been studied in humans?
A: Yes. Ipamorelin has been investigated in controlled human pharmacokinetic/pharmacodynamic research involving healthy volunteers. These studies characterized peptide exposure and GH-response kinetics but should not be interpreted as evidence that a research-grade commercial product is an approved medicine.
Q: Does Ipamorelin selectively stimulate growth hormone?
A: In the original pharmacological characterization, ipamorelin showed a relative selectivity for GH release, and the study reported no significant ACTH or cortisol response compared with GHRH under its experimental conditions. This is an experimental finding and should not be generalized beyond the studied models and conditions.
Q: What documentation is available with Ipamorelin orders?
A: Batch-specific analytical documentation may include a Certificate of Analysis (COA) and relevant chromatographic or mass-spectrometry data, depending on the specific production batch.
Q: Do you offer bulk quantities of Ipamorelin?
A: Bulk research supply can be discussed for qualified laboratories and institutional requirements. Researchers can contact Peptology Store for current availability and batch documentation.
Q: Do you ship Ipamorelin to EU countries?
A: Research-product availability and shipping options can be confirmed through peptology.store. Researchers should verify applicable destination-country requirements before ordering.
Q: Is Ipamorelin suitable for comparative secretagogue research?
A: Yes. Ipamorelin can be incorporated into comparative experimental designs alongside GHRP-2, GHRP-6, hexarelin, GHRH-related peptides, and other GHSR ligands to investigate differences in receptor activity and endocrine responses.
Advance Your Research with Ipamorelin 5mg
Peptology Store provides Ipamorelin 5mg for researchers investigating growth hormone secretagogue receptor biology, pituitary physiology, endocrine regulation, receptor pharmacology, and neuroendocrine signaling.
Whether your research focuses on GHSR activation, somatotroph signaling, comparative secretagogue pharmacology, receptor selectivity, or pharmacokinetic and pharmacodynamic relationships, Ipamorelin 5mg provides a defined synthetic peptide model for controlled laboratory investigation.
Its established experimental literature, including cellular, animal, and controlled human pharmacological studies, provides a foundation for continued research while leaving questions of therapeutic efficacy and safety separate from research-compound use.
Order today and experience the Peptology Store difference – premium quality, rapid 48-hour delivery across the EU and UK, and expert support for the European research community.
