Kisspeptin 10 5mg – High-Quality Research Peptide | 48-Hour Delivery Across EU & UK
KISSPEPTIN-10 5mg: Research-Grade Neuroendocrine Peptide for Reproductive & Hormonal Signaling Studies
peptology.store is proud to present KISSPEPTIN-10 5mg, a research-grade peptide supplied for laboratory investigations into kisspeptin signaling, reproductive neuroendocrinology, gonadotropin-releasing hormone (GnRH) regulation, hypothalamic-pituitary-gonadal (HPG) axis biology, and related endocrine pathways.
Kisspeptin-10 (KISS-10) is a biologically active fragment of the larger kisspeptin family of peptides encoded by the KISS1 gene. Kisspeptin signaling is closely associated with the regulation of GnRH neurons through the KISS1R/GPR54 receptor, making kisspeptin an important experimental system for studying reproductive endocrine signaling.
As a dedicated EU peptide supplier and peptide vendor UK, Peptology Store provides research compounds with documented specifications and batch-specific analytical information intended to support controlled laboratory workflows.
Whether your laboratory is based in London, Berlin, Paris, or anywhere in the European Union, our guaranteed 48 hour delivery peptide service ensures your essential supplies arrive when you need them.
The Scientific Foundation of KISSPEPTIN-10 Research
Discovery and Biological Significance
Kisspeptin is derived from the KISS1 gene and is processed into several biologically active peptides, including kisspeptin-54, kisspeptin-14, kisspeptin-13, and kisspeptin-10.
Kisspeptin peptides attracted major scientific interest following the discovery that their receptor, originally identified as GPR54 and now commonly known as KISS1R, plays an important role in reproductive neuroendocrine signaling.
Research has established kisspeptin signaling as an important upstream regulator of GnRH neurons and therefore a valuable experimental system for studying:
- Reproductive endocrinology
- GnRH neuronal signaling
- Gonadotropin regulation
- Pubertal development
- HPG-axis physiology
- Fertility-associated signaling
Structure and Classification
KISSPEPTIN-10 is a 10-amino-acid peptide fragment derived from the C-terminal region of kisspeptin.
The sequence is commonly represented as:
Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
Its C-terminal amidation is an important structural feature associated with biological activity.
KISS1R / GPR54 Signaling
Kisspeptin-10 acts through the KISS1R/GPR54 receptor, a G-protein-coupled receptor expressed on GnRH neurons and other tissues.
KISS1R activation has been associated with intracellular signaling involving:
- Phospholipase C
- Inositol trisphosphate (IP₃)
- Diacylglycerol (DAG)
- Intracellular calcium
- Protein kinase C
- Neuronal excitation
- GnRH secretion
This makes KISSPEPTIN-10 an important experimental ligand for investigating receptor-mediated neuroendocrine signaling.
Regulation of GnRH Signaling
One of the central areas of kisspeptin research concerns its ability to influence GnRH neuronal activity.
Kisspeptin signaling provides a framework for investigating how hypothalamic neurons communicate with the reproductive endocrine system and regulate downstream gonadotropin secretion.
Key Research Applications
Reproductive Neuroendocrinology
KISSPEPTIN-10 is extensively investigated in research involving the neuroendocrine control of reproduction.
Research applications include:
- GnRH Neuron Studies: Investigate activation and regulation of GnRH neurons
- HPG-Axis Research: Examine hypothalamic-pituitary-gonadal signaling
- Gonadotropin Regulation: Study downstream LH and FSH signaling
- Reproductive Hormone Research: Investigate neuroendocrine control of reproductive hormones
- Hypothalamic Signaling: Examine communication between kisspeptin neurons and reproductive endocrine pathways
Puberty and Developmental Research
Kisspeptin signaling has been strongly associated with reproductive maturation and pubertal development.
Research models may investigate:
- Pubertal onset
- Hypothalamic maturation
- GnRH neuronal activation
- KISS1 gene expression
- KISS1R signaling
- Developmental changes in reproductive endocrine function
GnRH and Gonadotropin Research
KISSPEPTIN-10 provides an experimental tool for investigating the relationship between kisspeptin signaling and downstream reproductive hormones.
Research may examine:
- GnRH secretion
- LH secretion
- FSH regulation
- Pulsatile reproductive signaling
- Pituitary responses
- Feedback mechanisms
Fertility and Reproductive Biology Research
Kisspeptin signaling is an important area of experimental fertility research because of its position within the reproductive endocrine pathway.
Potential research applications include:
- Gametogenesis-associated signaling
- Reproductive hormone regulation
- Gonadal function
- Fertility-associated endocrine mechanisms
- Reproductive-axis dysfunction models
Sex-Steroid Feedback Research
Kisspeptin neurons are responsive to reproductive hormone feedback, making KISSPEPTIN-10 useful for investigating interactions between sex steroids and hypothalamic signaling.
Research areas include:
- Estrogen feedback
- Testosterone feedback
- Progesterone-associated signaling
- KISS1 expression
- GnRH neuronal regulation
Neuroendocrine Signaling Research
KISSPEPTIN-10 can also be used as a defined ligand for investigating neuroendocrine communication.
Researchers may study:
- GPCR signaling
- Neuronal activation
- Intracellular calcium signaling
- Peptide-receptor interactions
- Hypothalamic neuronal networks
Quality Assurance: Setting the Standard for Research Compounds
Manufacturing Excellence
peptology.store supplies KISSPEPTIN-10 5mg with an emphasis on analytical quality and batch traceability.
Quality documentation may include:
- HPLC Purity Analysis: Batch-specific chromatographic assessment
- Mass Spectrometry Verification: Molecular identity and molecular-weight confirmation
- Batch-Specific Certificates of Analysis: Documentation associated with individual production lots
- Lyophilized Presentation: Dry format intended for appropriate laboratory storage
- Research-Use-Only Labelling: Clearly designated for laboratory research
- Batch Consistency: Quality-control procedures intended to support reproducible research
| Molecular Weight (g/mol) | 1302.45 g/mol |
| Peptide Sequence | YNWNSFGLRF |
Physical and Chemical Properties
|
|
| Molecular Formula | C63H83N17O14 |
| Physical Appearance | White lyophilised solid |
| Form | Sterile filtered white lyophilized (freeze-dried) |
| Solubility | Aqueous soluble |
| Appearance | White to off-white lyophilised powder |
| Melting Point | Not applicable (decomposes before melting) |
| Analytical and Quality Control | |
| HPLC Result | Shows min 98% purity |
| Mass Spectrum | Consistent with structure |
| Purity % | >98% |
| Research Use and Safety | |
| Caution | Research use only / Not for human or veterinary use |
| Intended Use | For laboratory research use only. Not for human or veterinary use. |
| Hazard Classification | Not classified as hazardous under GHS for research quantities |
| Storage, Handling and Stability | |
| Storage Temperature, Opened | Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18°C. Upon reconstitution of the peptide it should be stored at 4°C between 2-21 days and for future use below -18°C. |
| Storage Temperature, Unopened | -20 °C recommended for long-term storage |
| Shelf Life | 2 years unopened under recommended conditions |
| Reconstitution Stability | Stable for up to 28 days at 2-8 °C in aqueous solution under sterile conditions |
Stability and Handling
KISSPEPTIN-10 5mg should be handled according to the product-specific documentation and established laboratory procedures.
- Lyophilized Material: Store according to the temperature specified in the applicable product documentation.
- Light Protection: Protect the material from unnecessary direct light exposure.
- Moisture Protection: Keep the vial tightly sealed and protected from humidity.
- Reconstituted Material: Establish storage conditions according to validated laboratory procedures and available stability information.
- Aliquoting: Where appropriate, aliquot prepared research solutions to minimize repeated freeze-thaw exposure.
- Temperature Control: Avoid unnecessary temperature fluctuations.
- Documentation: Record preparation and storage conditions as part of the experimental record.
Real-World Research Applications and Investigator Studies
GnRH Neuron Activation Studies
Kisspeptin is one of the best-characterized upstream regulators of GnRH neuronal activity.
Experimental studies can use KISSPEPTIN-10 to investigate:
- GnRH neuronal activation
- Neuronal depolarization
- Intracellular calcium signaling
- GnRH secretion
- Kisspeptin-KISS1R interactions
KISS1R Receptor Studies
KISSPEPTIN-10 provides a defined ligand for investigating KISS1R/GPR54 receptor pharmacology.
Researchers may examine:
- Receptor activation
- Ligand-receptor interactions
- GPCR signaling
- Intracellular calcium responses
- PLC/IP₃/DAG signaling
- Receptor sensitivity
Puberty Research
Kisspeptin signaling is strongly associated with the initiation and maintenance of reproductive maturation.
Research can investigate:
- KISS1 expression during development
- KISS1R expression
- GnRH activation
- Pubertal endocrine transitions
- Sex-steroid feedback
Reproductive Hormone Studies
Experimental research can examine how kisspeptin signaling influences downstream reproductive hormones.
Potential endpoints include:
- LH secretion
- FSH secretion
- GnRH release
- Sex-steroid signaling
- HPG-axis activity
Sex-Steroid Feedback Studies
Kisspeptin neurons participate in feedback interactions involving reproductive hormones.
Researchers can investigate how:
- Estrogen
- Testosterone
- Progesterone
- Other endocrine signals
influence KISS1/KISS1R signaling and downstream reproductive pathways.
Key Research Features
- 5mg Research Presentation
- Kisspeptin-10 / KISS-10
- KISS1R / GPR54 Research
- GnRH Neuron Studies
- Reproductive Neuroendocrinology
- HPG-Axis Research
- Gonadotropin Research
- Puberty and Developmental Studies
- Fertility-Associated Research
- Sex-Steroid Feedback Studies
- GPCR Signaling Research
- Intracellular Calcium Research
- Neuroendocrine Research
- Lyophilized Research Format
- Batch-Specific Documentation
- Research-Use-Only Material
- Laboratory-Oriented Handling Guidance
- EU & UK Research Supply through Peptology Store
Frequently Asked Questions
Q: What is KISSPEPTIN-10?
A: KISSPEPTIN-10 is a biologically active 10-amino-acid fragment of the kisspeptin family. It has been extensively investigated as a ligand for the KISS1R/GPR54 receptor and as an experimental regulator of GnRH neuronal signaling.
Q: What is KISSPEPTIN-10 5mg used for?
A: KISSPEPTIN-10 5mg is supplied for laboratory research involving KISS1R signaling, GnRH neurons, reproductive endocrinology, HPG-axis regulation, gonadotropin signaling, puberty research, and neuroendocrine biology.
Q: What receptor does KISSPEPTIN-10 target?
A: KISSPEPTIN-10 acts primarily through the KISS1R/GPR54 receptor, a GPCR associated with kisspeptin-mediated neuroendocrine signaling.
Q: What research areas commonly investigate KISSPEPTIN-10?
A: Research applications include GnRH signaling, reproductive neuroendocrinology, puberty research, HPG-axis biology, gonadotropin regulation, fertility-associated research, sex-steroid feedback, and GPCR pharmacology.
Q: What is the sequence of KISSPEPTIN-10?
A: KISSPEPTIN-10 is commonly represented as Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂.
Q: How does KISSPEPTIN-10 influence GnRH research?
A: Kisspeptin signaling through KISS1R is an important upstream pathway regulating GnRH neuronal activity. KISSPEPTIN-10 therefore provides a useful experimental ligand for investigating GnRH-related neuroendocrine signaling.
Q: Is KISSPEPTIN-10 suitable for human consumption?
A: No. KISSPEPTIN-10 5mg supplied by peptology.store is intended for research and laboratory use only and is not supplied as an approved therapeutic product.
Q: Can KISSPEPTIN-10 be used in cell-based research?
A: Yes. KISSPEPTIN-10 can be investigated in appropriate in-vitro systems involving KISS1R-expressing cells or relevant neuroendocrine models. Researchers should determine concentrations, exposure periods, controls, and assay conditions according to validated laboratory protocols.
Q: What intracellular pathways are associated with KISS1R activation?
A: KISS1R activation has been associated with G-protein-mediated signaling involving phospholipase C, IP₃, DAG, intracellular calcium, and protein kinase C pathways.
Q: Is KISSPEPTIN-10 studied in puberty research?
A: Yes. Kisspeptin/KISS1R signaling has an important role in research examining the neuroendocrine mechanisms underlying reproductive maturation and puberty.
Q: Is KISSPEPTIN-10 studied in fertility research?
A: Yes. Because kisspeptin signaling is closely connected to GnRH and gonadotropin regulation, it is widely investigated in experimental reproductive and fertility research.
Q: How should KISSPEPTIN-10 be stored?
A: Store the lyophilized research material according to the product-specific storage instructions. Protect it from moisture, unnecessary light exposure, and unsuitable temperature conditions. Reconstituted material should be handled according to an appropriate laboratory stability protocol.
Q: What documentation is provided with KISSPEPTIN-10 orders?
A: Batch-specific analytical documentation may include a Certificate of Analysis (COA) and relevant chromatographic or mass-spectrometry information, depending on the production batch.
Q: Do you offer bulk quantities of KISSPEPTIN-10?
A: Bulk research supply can be discussed for qualified laboratories and institutional research programs. Contact Peptology Store for current availability and batch documentation.
Q: Do you ship KISSPEPTIN-10 to EU countries?
A: Research-product availability and shipping options can be confirmed through peptology.store. Researchers should verify applicable destination-country requirements before ordering.
Q: Is KISSPEPTIN-10 an approved fertility treatment?
A: KISSPEPTIN-10 should be treated as a research compound in this product context. Experimental findings involving kisspeptin signaling should not be presented as evidence that a research-grade product is an approved fertility treatment or established therapeutic.
Advance Your Research with KISSPEPTIN-10 5mg
Peptology Store provides KISSPEPTIN-10 5mg for researchers investigating KISS1R/GPR54 signaling, GnRH neuronal biology, reproductive endocrinology, puberty, gonadotropin regulation, and HPG-axis physiology.
Whether your research focuses on GPCR pharmacology, hypothalamic signaling, reproductive neuroendocrinology, sex-steroid feedback, or kisspeptin-mediated GnRH regulation, KISSPEPTIN-10 provides a defined peptide model for controlled laboratory investigation.
With batch-specific analytical documentation and research-focused handling information, KISSPEPTIN-10 5mg can be incorporated into appropriately designed experimental workflows where analytical consistency and traceability are important.
Order today and experience the Peptology Store difference – premium quality, rapid 48-hour delivery across the EU and UK, and expert support for the European research community.
